The last time the Jets defense faced EJ Manuel in week three they sacked him 8 times and hit him 16 times. This time, the defense is well-rested coming off a bye. Muhammad Wilkerson, Sheldon Richardson, and Harrison all dominated last time against the Bills. Guys like Antonio Cromartie and Dee Milliner should be 100% this time, and the Jets just signed veteran Ed Reed.
It's amazing what Geno Smith has done with so little weapons. This week in Buffalo his luck changes, as he will get Kellen Winslow, Jeff Cumberland, and Santonio Holmes all back in his offense. Holmes torched the Bills back in week three, and Cumberland and Winslow are Geno's two favorite red-zone targets. These three weapons give the Jets a huge advantage against the Bills.
The Bills may struggle, but without Stevie Johnson and Robert Woods it could be bad. Woods has already been declared out and Johnson hasn't practiced all week. Manuel being without two big receivers would be horrible.